The impact of high-cholesterol diet feeding on hepatic mRNA and small non-coding RNA profiles in mice
Non-coding RNA profiling · mouse · 25 samples
- What it is
- Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 19 distinct titles, 1 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis developmentNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300043_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
Also filed as BioProject PRJNA1278733 and SRA study SRP517842. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 25 sample titles: 19 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8376917 LiLP1_S31
- GSM8376918 LiLP2_S32
- GSM8376919 LiLP3_S33
- GSM8376920 LiLP4_S34
- GSM8376921 LiLP5_S35
- GSM8376922 LiLP15_S45
- GSM8376923 LiLP16_S46
- GSM8376924 LiLP17_S47
- GSM8376925 LiLP18_S48
- GSM8376926 LiLT1_S49
- GSM8376927 LiLT2_S50
- GSM8376928 LiLT3_S51
- GSM8376929 LiLT4_S52
- GSM8376930 LiLT5_S53
- GSM8376931 LiLT15_S63
- GSM8376932 LiLT16_S64
- GSM8376933 LiLT17_S65
- GSM8376934 LiLT18_S66
- GSM9048012 XCL2
- GSM9048013 XCL3
- GSM9048014 XCL4
- GSM9048015 XCL5
- GSM9048016 XCL6
- GSM9048017 XCL7
- GSM9048018 XCL8
- GSE272793 An atlas of small non-coding RNAs in Human Preimplantation Development (Mouse embryo RNA-seq) 132 samples shares non-coding, small
- GSE267751 Time-restricted feeding prevents memory impairments induced by obesogenic diet consumption in mice, in part through hippocampal thyroid hormone signaling. 71 samples shares feeding, diet
- GSE248222 Impact of Maternal Immune Activation and Sex on Placental and Fetal Brain Cytokine and Gene Expression Profiles in a Preclinical Model of Neurodevelopmental Disorders 64 samples shares profiles, impact
- GSE263895 Both host and parasite non-coding RNAs co-ordinate the regulation of macrophage gene expression to reduce pro-inflammatory immune responses and promote tissue repair pathways during infection with fasciola hepatica 40 samples shares non-coding, hepatic
- GSE304113 Establishment of sex-specific liver transcriptomes and H3K9me3 profiles during sexual maturity: the impact of maternal obesity [ChIP-seq] 36 samples shares profiles, impact
- GSE252343 Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity 34 samples shares profiles, diet
- GSE304112 Establishment of sex-specific liver transcriptomes and H3K9me3 profiles during sexual maturity: the impact of maternal obesity [RNA-seq] 32 samples shares profiles, impact
- GSE252429 Small non-coding RNAs encapsulating mammalian cells fuels innate immunity 24 samples shares non-coding, small
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.