← BioTransfer GEO Dataset Finder
GEO series

Targeting Menin in T-Lineage Acute Lymphoblastic Leukemia [MEF2CKD]

GSE300109 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/03/01 Platform GPL34281
Summary
The efficacy of menin inhibition was evaluated in 14 primary T-ALL samples with diverse genetic backgrounds using ziftomenib. Sensitivity was not correlated with HOXA expression or KMT2A rearrangements, and in vivo treatment significantly reduced tumor burden in xenograft models without notable toxicity. Transcriptomic and proteomic analyses confirmed on-target activity, including downregulation of menin targets and activation of differentiation pathways. Phosphoproteomic profiling identified phospho-MEF2C (S222) as a key marker of sensitivity, regulated by CDK and MAPK signaling. Combination treatment with ziftomenib and CDK1/2 or ERK1/2 inhibitors showed synergistic effects, suggesting a mechanistic link between menin inhibition and p-MEF2C–driven T-ALL vulnerability.
Published in
Targeting Menin in T-lineage Acute Lymphoblastic Leukemia
Shimamoto K, Karaoglu DA, Arnold O et al. · Molecular cancer therapeutics 2026 · PMID 41778833 · doi:10.1158/1535-7163.MCT-25-0969
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE300109_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1279041 and SRA study SRP592858. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.