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Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

GSE300177 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 194 samples Submitted 2025/06/19 Platform GPL24676Platform GPL30173
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 194 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Samples
194 samples: 84 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL LeukemiaCancer discovery · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
Catalytic Inhibition of KAT6/KAT7 Enhances the Efficacy and Overcomes Primary and Acquired Resistance to Menin Inhibitors in MLL Leukemia
Gordon SJV, Perner F, MacPherson L et al. · Cancer discovery 2025 · PMID 40536420 · doi:10.1158/2159-8290.CD-24-1517
This dataset
Open GSE300177 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300177_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1279172 and SRA study SRP532497. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40536420) ↗
Study design
84 conditions, mostly in duplicate
Molm-13, 2500nM PF-9363, 24hrs, ×3 Molm-13, Vehicle, 24hrs, ×3 Molm-13, 100nm VTP, 24hrs, ×3 Molm-13, 100nm VTP, 2500nM PF-9363, 24hrs, ×3 Molm-13, 2500nM PF-9363, 6hrs, ×3 Molm-13, Vehicle, 6hrs, ×3 Molm-13, 100nm VTP, 6hrs, ×3 Molm-13, 100nm VTP, 2500nM PF-9363, 6hrs, ×3 +94 more

Supports a case/control comparison: 2 samples read as cases, 66 as controls.

How we read this: 84 replicated groups read from 194 sample titles; they account for 176 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 154 more — browse all 194 samples with per-sample file links →

Datasets on a similar topic

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Share this dataset

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