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Loss of WWOX Drives Cutaneous Squamous Cell Carcinoma (cSCC) through Regulating EMT

GSE300270 Homo sapiens (human) ChIP-seq / ATAC-seq (genome binding and open chromatin) 24 samples Submitted 2026/04/01 Platform GPL24676Platform GPL24247
At a glance

ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 24 samples

What it is
ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
Organism
Homo sapiens (human)
Topic
Cutaneous squamous cell carcinomaThis series is part of our curated briefing on it.
Samples
24 samples: 7 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinomaProceedings of the National Academy of Sciences of the United States of America · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
WWOX maintains epidermal identity and suppresses EMT to prevent aggressive cutaneous squamous cell carcinoma
Bidany-Mizrahi T, Maroun K, Mancini M et al. · Proceedings of the National Academy of Sciences of the United States of America 2026 · PMID 41984841 · doi:10.1073/pnas.2534844123
This dataset
Open GSE300270 in finder → Find more ChIP / ATAC / CUT&Tag datasets → Cutaneous squamous cell carcinoma landscape →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300270_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.

Also filed as BioProject PRJNA1279994 and SRA study SRP593331. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41984841) ↗
Study design
7 conditions, mostly in triplicate
tdTom+ cells of cSCC from K14cre;p53fl/fl mic… ×3 tdTom+ cells of cSCC from K14cre;Wwoxfl/fl;p5… ×3 tdTom+ cells of young Wild-type epidrmis, ×3 tdTom+ cells of young K14cre;Wwoxfl/fl epidrm… ×3 tdTom+ cells of young K14cre;p53fl/fl epidrmi… ×3 tdTom+ cells of young K14cre;Wwoxfl/fl;p53fl/… ×3 tdTom+ cells of old Wild-type epidrmis, ×2 A431 cells shp53, WWOX Wild-Type ×1 +3 more

Supports a between-group comparison across 20 samples.

How we read this: 7 replicated groups read from 24 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
More Cutaneous squamous cell carcinoma datasets

Search all ChIP / ATAC / CUT&Tag datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.