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snRNA-seq of Sandhoff disease brain cells

GSE300356 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/06/24 Platform GPL30882
Summary
We used snRNA-sequencing to analzye thalamic brain nuclei (NeuN-;Olig2-) derived from Sandhoff disease patients and unaffected controls
Published in
Microglia-neuron crosstalk through Hex-GM2-MGL2 maintains brain homeostasis
Frosch M, Shimizu T, Wogram E et al. · Nature 2025 · PMID 40769205 · doi:10.1038/s41586-025-09477-y
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Direct links to NCBI, no account and no request form: the whole study as GSE300356_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1280134 and SRA study SRP593451. Searching any of these in the dataset finder brings you back here.

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