GEO series
Targeting Thioredoxin Reductase 1 (TrxR1) Uncovers Ferroptosis-Linked Transcriptional Vulnerabilities in Lung Cancer
GSE300378
Homo sapiens
Expression profiling by high throughput sequencing
33 samples
2026/06/30
GPL18573
Summary
Bulk RNA sequencing revealed that KRAS-WT and EGFR-MUT LC cells, which are sensitive to TrxR1 inhibitors (CS47 and auranofin), undergo extensive transcriptional reprogramming, unlike the treatment-resistant KRAS-mutant (KRAS-MUT) cells. TrxR inhibition triggers robust transcriptional activation of glutathione biosynthesis, antioxidant defenses, and iron metabolism in KRAS-WT lung cancer cells. This adaptive response, while aimed at maintaining redox balance, is ultimately overwhelmed, leading to ferroptotic cell death.
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