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Single nuclei RNAseq of human Rett syndrome neurons cortical samples after sorting for MECP2 expression

GSE300482 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/06/23 Platform GPL34281
Summary
Here we employed sc-RNA-seq on nuclei from MECP2 Syndrome brain and normal brain to understand the effect of loss of MECP2 on neurons compared to both MECP2+ neurons in isogenic MECP2 Syndrome brain, as well as to WT brain to determine which changes are due directly to loss of MECP2, and in transgenic rats lacking MECP2.
Published in
Evidence of neuronal DNA damage in the brains of patients with Rett syndrome
Morales A, Korsakova E, Mansooralavi N et al. · Disease models & mechanisms 2025 · PMID 40739790 · doi:10.1242/dmm.052358
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Also filed as BioProject PRJNA1281027 and SRA study SRP594080. Searching any of these in the dataset finder brings you back here.

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