GEO series
EGR proteins mediate interferon-independent anti-HSV-1 responses through viral and host targets
GSE300560
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/12/13
GPL28457
Summary
Herpes simplex virus type I (HSV-1) establishes a latent infection that evades the host's defense system, and the latent virus can be reactivated by some stimulation. At present,a key problem in the latent studies of HSV-1 has not been clarified, that is, HSV-1 mainly selectively latent in neurons. Therefore, we have found the host transcription factor EGR in Neuro-2a cells by RNA-seq. EGR1 regulates HSV-1 replication and latency by binding to the viral genome or recruiting co-factors. Our data intend to find the role and mechanism of EGR family repressing HSV-1 replication and promoting HSV-1 latency. This study will provide a theoretical basis for the development of drugs to treat of HSV-1 infection.
Download
NCBI GEO page ↗
Paper (PMID 41486724) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
mouse RNA-seq datasets →
Similar datasets
- GSE292862 Modelling mouse embryogenesis from chemically induced totipotent stem cells 22 samples
- GSE185862 A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation 95 samples
- GSE293315 MRPGRX2 Antagonist Treatment Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis Dataset 2 35 samples
- GSE255837 Dysregulation of the Normal Wound Healing Cascade in Volumetric Muscle Loss Injury 30 samples
- GSE341948 Multi-tissue transcriptomic landscape reveals synergistic mechanisms of exercise and GLP-1 agonist in ameliorating diabetic phenotypes in db/db mice 12 samples
- GSE304862 Semaglutide and exercise synergy in obesity: preserving muscle mass and uncovering organ crosstalk 209 samples
- GSE337190 CAR-NKT cells induce low cytokine release syndrome by targeting hyperinflammatory macrophages with mitigation from GM-SCF inhibition. 24 samples
- GSE306116 Caspase-3 Control of RNA Splicing and Mitochondrial Dynamics in Microglia during Parkinson’s Disease [RNA-Seq] 12 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.