EGR proteins mediate interferon-independent anti-HSV-1 responses through viral and host targets
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EGR Proteins Mediate Interferon-Independent Anti-HSV-1 Responses Through Viral and Host TargetsAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300560_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1281182 and SRA study SRP594007. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9064542 Neuro-2a cells( knockout EGR1), pcDNA1,10hpi
- GSM9064543 Neuro-2a cells( knockout EGR1), pcDNA2,10hpi
- GSM9064544 Neuro-2a cells( knockout EGR1), pcDNA3,10hpi
- GSM9064545 Neuro-2a cells( knockout EGR1), EGR1human1,10hpi
- GSM9064546 Neuro-2a cells( knockout EGR1), EGR1human2,10hpi
- GSM9064547 Neuro-2a cells( knockout EGR1), EGR1human3,10hpi
- GSM9064548 Neuro-2a cells( knockout EGR1),pc1,3hpi
- GSM9064549 Neuro-2a cells( knockout EGR1),pc2,3hpi
- GSM9064550 Neuro-2a cells( knockout EGR1),pc3,3hpi
- GSM9064551 Neuro-2a cells( knockout EGR1),e1human1,3hpi
- GSM9064552 Neuro-2a cells( knockout EGR1),e1human2,3hpi
- GSM9064553 Neuro-2a cells( knockout EGR1),e1human3,3hpi
- GSE277303 Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis 42 samples shares egr, mediate
- GSE293160 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [RNA-seq] 24 samples shares egr, mediate
- GSE300933 Ptpn2 limits plasma cell fate and antiviral immunity by integrating B cell receptor and IFN-γ signals in B cells 23 samples shares egr, viral
- GSE274930 ZMAT1 promotes osteoclast formation and bone loss through TRIM46 mediated YAP1 degradation II 18 samples shares egr, mediate
- GSE285474 Diabetic hyperglycemia-induced glycation regulates tumor vasculature integrity via NF-κB-mediated GM-CSF secretion by tumor cells 14 samples shares egr, mediate
- GSE297309 SKP1A-mediated degradation of PRC2 triggers activation of Polycomb-silenced gene [CUT&Tag] 108 samples shares egr, mediate
- GSE283906 RXR-Mediated Remodeling of Transcriptional and Chromatin Landscapes in APP Mouse Brain: Insights from Integrated Single-Cell RNA and ATAC Profiling 10 samples shares egr, mediate
- GSE308859 Integrated Spatial Transcriptomics and Single-Cell RNA Sequencing Reveal Lars2-Mediated Spatiotemporal Dynamics of Myocardial Remodeling in a Mouse Model of Transverse Aortic Constriction (TAC) 8 samples shares egr, mediate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.