GEO series
Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma
GSE300868
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
10 samples
2026/06/01
GPL24676
Summary
We introduced hundreds of CRISPR–Cas9-mediated DNA double-strand breaks (DSBs) into glioblastoma stem-like cells and tracked chromatin, transcriptional, and structural changes over time. Long after the DSBs were repaired, we found durable reprogramming of chromatin conformation and gene expression, as well as emergence of structural variants. These findings suggest that DNA damage can induce stable non-genetic alterations in cancer cells.
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