Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neurons
RNA-seq (gene expression) · human · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 28 samples: 28 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mitochondrial toxins cause widespread downregulation of pathways in X-linked dystonia-parkinsonism patient-derived neuronsStem cell reports · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300875_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1282491 and SRA study SRP594760. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 14 samples read as cases, 14 as controls.
How we read this: Read from 28 sample titles: 28 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9070303 H21154_Patient_NT
- GSM9070304 H21155_Patient_NT
- GSM9070305 H21156_Control_NT
- GSM9070306 H21157_Control_NT
- GSM9070307 H21164_Patient_NT
- GSM9070308 H21165_Patient_NT
- GSM9070309 H21166_Control_NT
- GSM9070310 H21167_Control_NT
- GSM9070311 H21172_Patient_MMP
- GSM9070312 H21173_Control_MMP
- GSM9070313 H21174_Patient_NT
- GSM9070314 H21175_Patient_NT
- GSM9070315 H21176_Control_NT
- GSM9070316 H21177_Control_NT
- GSM9070317 H21178_Patient_Rotenone
- GSM9070318 H21179_Patient_Rotenone
- GSM9070319 H21181_Control_Rotenone
- GSM9070320 H21182_Patient_MMP
- GSM9070321 H21183_Control_MMP
- GSM9070322 H21184_Patient_NT
- GSM9070323 H21185_Patient_NT
- GSM9070324 H21186_Control_NT
- GSM9070325 H21187_Control_NT
- GSM9070326 H21188_Patient_Rotenone
- GSM9070327 H21190_Control_Rotenone
- GSM9070328 H21191_Control_Rotenone
- GSM9070329 H21192_Patient_MMP
- GSM9070330 H21193_Control_MMP
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- GSE274283 Bulk RNA sequencing analysis of a iPSC-derived neurons, microglia and astrocytes models of mitochondrial unfolded protein response (UPRmt) activation. 18 samples shares mitochondrial, neurons
- GSE301408 Mitochondrial double-stranded RNA triggers chronic stress in aged neurons 100 samples shares mitochondrial, neurons
- GSE317901 Unraveling cetuximab response in head and neck cancer with APHRODYTHE, a multi-omics patient-derived xenograft platform 114 samples shares patient-derived
- GSE334033 A Patient-Derived Xenograft Model Identifies AK1 as a Key Regulator of Metastatic Potential in Primary Triple-Negative Breast Cancer 105 samples shares patient-derived
- GSE336577 Integrated Transcriptomic and Immune Analysis Reveals Distinct Mitochondrial and Immune Signature in COVID-19 ARDS Requiring Invasive Mechanical Ventilation 94 samples shares mitochondrial
- GSE241261 Integrated analysis of transcriptional and metabolic responses to mitochondrial stress 72 samples shares mitochondrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.