Identification of GREM-1 and GAS6 as specific biomarkers for cancer-associated fibroblasts derived from patients with non-small cell lung cancer
RNA-seq (gene expression) · human · 33 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 33 samples: 33 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Identification of GREM-1 and GAS6 as Specific Biomarkers for Cancer-Associated Fibroblasts Derived from Patients with Non-Small-Cell Lung CancerCancers · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE300983_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1282936. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 33 sample titles: 33 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9073048 patient TH79 cells, cancer-associated fibroblast from lymph node
- GSM9073049 patient TH84 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073050 patient TH98 cells, normal fibroblast from lung (non-tumor)
- GSM9073051 patient TH98 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073052 patient TH106 cells, cancer-associated fibroblast from lymph node
- GSM9073053 patient TH107 cells, normal fibroblast from lung (non-tumor)
- GSM9073054 patient TH107 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073055 patient TH114 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073056 patient TH128 cells, cancer-associated fibroblast from lymph node
- GSM9073057 patient TH120 cells, normal fibroblast from lung (non-tumor)
- GSM9073058 patient TH120 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073059 patient TH122 cells, normal fibroblast from lung (non-tumor)
- GSM9073060 patient TH122 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073061 patient TH131 cells, normal fibroblast from lung (non-tumor)
- GSM9073062 patient TH131 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073063 patient TH138 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073064 patient TH141 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073065 patient TH147 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073066 patient TH110 cells, cancer-associated fibroblast from lymph node
- GSM9073067 patient TH89 cells, normal fibroblast from lung (non-tumor)
- GSM9073068 patient TH89 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073069 patient TH100 cells, normal fibroblast from lung (non-tumor)
- GSM9073070 patient TH100 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073071 patient TH127 cells, normal fibroblast from lung (non-tumor)
- GSM9073072 patient TH127 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073073 patient TH137 cells, normal fibroblast from lung (non-tumor)
- GSM9073074 patient TH137 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073075 patient TH153 cells, normal fibroblast from lung (non-tumor)
- GSM9073076 patient TH153 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073077 patient TH157 cells, cancer-associated fibroblast from lymph node
- GSM9073078 patient TH160 cells, cancer-associated fibroblast from lymph node
- GSM9073079 patient TH165 cells, cancer-associated fibroblast from lung (tumor)
- GSM9073080 patient TH85 cells, normal fibroblast from lung (non-tumor)
- GSE241518 High-throughout sequencing of colorectal cancer and non-small cell lung cancer cells treated actived compound YHM18 4 samples same disease briefing · shares non-small
- GSE114761 Transforming Growth Factor β-Induced Epithelial-to-Mesenchymal Signature Predicts Metastasis-Free Survival in Non-Small Cell Lung Cancer. 42 samples same disease briefing · shares non-small
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing · shares derived
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing
- GSE117570 Reprogramming of Tumor-infiltrating Immune Cells in Early Stage of NSCLC 8 samples same disease briefing
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.