GEO series
Phosphatase-independent suppression of mucosal inflammation and disease progression by Salmonella SopB
GSE300992
Mus musculus
Expression profiling by high throughput sequencing
11 samples
2026/06/21
GPL24247
Summary
The results of our current study show that Salmonella oter protein (SopB) suppresses early epithelial chemokine expression, delays mucosal immune cell recruitment, reduces barrier impairment by enterocyte necroptosis, and prevents disease progression and premature death in our neonatal S. Typhimurium infection model. To elucidate the underlying mechanism, we have conducted bulk RNA sequencing to identify alterations in gene expression.
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