GEO series
Highly efficient generation of functional TCRγδ+ T cells from human embryonic stem cells
GSE301057
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/02/25
GPL24676
Summary
This dataset presents comprehensive RNA sequencing (RNA-seq) data documenting the dynamic transcriptional landscape during the in vitro differentiation of human embryonic stem cells (hESCs) into functional TCRγδ+ T cells. The study captures stage-specific gene expression patterns across key developmental transitions, including: (1) pluripotent stem cell stage, (2) hematopoietic progenitor specification, (3) T-lineage commitment, and (4) mature TCRγδ+ T cell maturation. The data reveal critical transcription factors governing γδ T cell development (e.g., EGR3, SOX13) and genes related to the proliferation and activation of T cells (e.g.,CD80, CD86, IL7R and IL15RA). Pathway analysis highlights dynamic regulation of WNT signaling,TGF-beta, PI3K-AKT, and cytokine-mediated pathways (IL-17) throughout the differentiation cascade.
Download
NCBI GEO page ↗
Paper (PMID 41617828) ↗
{# Names what the click gives you. "Open in finder" meant nothing to a
visitor who arrived from a search engine and has never seen the tool. #}
Find more
human RNA-seq datasets →
Similar datasets
- GSE328275 Single-cell RNA sequencing of CD45+ immune cells across primary tumor, sentinel tumor-draining lymph node, and axillary lymph node in treatment-naive triple-negative breast cancer 28 samples
- GSE341753 Cohesin loading at regulatory elements shapes 3D genome folding during erythropoiesis [RNA-Seq] 12 samples
- GSE319969 Spatial and Bulk Transcriptomic Profiling Defines the Molecular Evolution of Cutaneous Squamous Cell Carcinoma and Reveals Stage-Specific Biomarkers of Clinical Relevance [RNA-Seq] 24 samples
- GSE313035 METIMMOX: Colorectal Cancer METastasis - Shaping Anti-tumor IMMunity by OXaliplatin 67 samples
- GSE339456 Integrated bulk and spatial transcriptomic analysis identifies progression-associated molecular signatures in biopsy-proven hypertensive nephropathy [RNA-seq] 35 samples
- GSE342462 Integrated transcriptomic and bioelectrical profiling of stem-like cellular states in a colorectal cancer using SdFFF and UHF-DEP 12 samples
- GSE336982 Obesity Promotes Lung Carcinogenesis Through Airway Immune Dysfunction 183 samples
- GSE330029 Temporal changes in metabolism guide oligodendrocyte precursor cell dynamics in aging and multiple sclerosis [BulkRNAseq] 108 samples
Share this dataset
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.