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Menin regulates YBX1 nuclear translocation to drive HKDC1 transcription and restrain glycolysis in pancreatic ductal adenocarcinoma

GSE301126 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/03 Platform GPL24676
Summary
Menin suppresses glycolysis in PDAC by binding YBX1, promoting its nuclear import, and up-regulating HKDC1 transcription. RNA-seq on PL45 cells over-expressing Menin versus vector control identified 413 DEGs; key metabolic genes GLUT1 and LDHA were down-regulated, while HKDC1 was up-regulated. Findings highlight a Menin-YBX1-HKDC1 axis as a potential therapeutic target.
Published in
Menin regulates YBX1 nucleus translocation to boost the HKDC1 transcription and affects pancreatic cancer glycolysis
Ni C, Yang J, Lu Y et al. · iScience 2025 · PMID 40894906 · doi:10.1016/j.isci.2025.113245
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Also filed as BioProject PRJNA1284095 and SRA study SRP596201. Searching any of these in the dataset finder brings you back here.

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