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Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na+ channel dynamics in human neurons

GSE301134 Homo sapiens (human) RNA-seq (gene expression) 53 samples Submitted 2026/04/09 Platform GPL24676
At a glance

RNA-seq (gene expression) · human · 53 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
53 samples: 15 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na(+) channel dynamics in human neuronsMolecular psychiatry · 2026
Summary (written by the submitters)
Schizophrenia is a highly heritable psychiatric disorder, yet the molecular mechanisms by which genetic risk contributes to disease pathophysiology remain largely unknown. In this study, we investigate the functional consequences of XPO7 loss of function (LoF) in human induced pluripotent stem cell (iPSC)-derived neurons, focusing on its role as a schizophrenia risk gene identified through recent large-scale exome sequencing analyses.
Read the full summary ↓
By integrating high-precision electrophysiological measurements with transcriptomic, proteomic, and imaging approaches, we demonstrate that XPO7 LoF alters Na+ channel properties and availability, disrupts neuronal excitability, and impairs the synchrony and regularity of network activity. These functional deficits are accompanied by widespread molecular dysregulation affecting nucleocytoplasmic transport, ion channel function, and synaptic composition. Among the dysregulated proteins is Nav1.2, a voltage-gated sodium channel encoded by the schizophrenia-associated gene SCN2A, which exhibits aberrant subcellular distribution in XPO7 LoF neurons, characterized by increased somatic accumulation and reduced synaptic localization. Together, these findings position XPO7 as a critical regulator of neuronal excitability and connectivity, linking channelopathy to cellular phenotypes relevant to schizophrenia pathophysiology.
Published in
Loss of schizophrenia risk gene XPO7 disrupts neuronal excitability and network regularity via altered Na(+) channel dynamics in human neurons
Cui L, Kurganov E, Hawes D et al. · Molecular psychiatry 2026 · PMID 41986745 · doi:10.1038/s41380-026-03587-3
This dataset
Open GSE301134 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301134_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1284101 and SRA study SRP596010. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41986745) ↗
Study design
15 conditions, mostly in triplicate
iPSC-derived neurons, Day 42, XPO7+/+, replic… ×6 iPSC-derived neurons, Day 56, XPO7+/+, replic… ×6 iPSC-derived neurons, Day 28, XPO7+/+, replic… ×5 iPSC-derived neurons, Day 28, XPO7+/-, clone … ×3 iPSC-derived neurons, Day 28, XPO7+/-, clone … ×3 iPSC-derived neurons, Day 28, XPO7-/-, clone … ×3 iPSC-derived neurons, Day 28, XPO7-/-, clone … ×3 iPSC-derived neurons, Day 42, XPO7+/-, clone … ×3 +7 more

Supports a between-group comparison across 53 samples.

How we read this: 15 replicated groups read from 53 sample titles; they account for 53 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 13 more — browse all 53 samples with per-sample file links →

Datasets on a similar topic

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