Simultaneous Targeting of KRAS and CDK4 Synergistically Induces Durable Growth Arrest in Pancreatic Cancer Cells [AsPC-1_RNA_Seq]
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × AsPC-1 cells, DMSO, 24 h, vs 3 × AsPC-1 cells, Palbociclib, 24 h, vs 3 × AsPC-1 cells, Palbociclib+MRTX1133, 24 h, vs 2 × AsPC-1 cells, MRTX1133, 24 h,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Simultaneous targeting of KRAS and CDK4 synergistically induces durable growth arrest in pancreatic cancer cellsCell death & disease · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301148_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1284191 and SRA study SRP596260. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 11 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 11 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9076334 AsPC-1 cells, DMSO, 24 h, rep1 AsPC-1 cells, DMSO, 24 …
- GSM9076335 AsPC-1 cells, DMSO, 24 h, rep2 AsPC-1 cells, DMSO, 24 …
- GSM9076336 AsPC-1 cells, DMSO, 24 h, rep3 AsPC-1 cells, DMSO, 24 …
- GSM9076337 AsPC-1 cells, Palbociclib, 24 h, rep1 AsPC-1 cells, Palbocicl…
- GSM9076338 AsPC-1 cells, Palbociclib, 24 h, rep2 AsPC-1 cells, Palbocicl…
- GSM9076339 AsPC-1 cells, Palbociclib, 24 h, rep3 AsPC-1 cells, Palbocicl…
- GSM9076340 AsPC-1 cells, MRTX1133, 24 h, rep1 AsPC-1 cells, MRTX1133,…
- GSM9076341 AsPC-1 cells, MRTX1133 24 h, rep2
- GSM9076342 AsPC-1 cells, MRTX1133, 24 h, rep3 AsPC-1 cells, MRTX1133,…
- GSM9076343 AsPC-1 cells, Palbociclib+MRTX1133, 24 h, rep1 AsPC-1 cells, Palbocicl…
- GSM9076344 AsPC-1 cells, Palbociclib+MRTX1133, 24 h, rep2 AsPC-1 cells, Palbocicl…
- GSM9076345 AsPC-1 cells, Palbociclib+MRTX1133, 24 h, rep3 AsPC-1 cells, Palbocicl…
- GSE295683 RNA-seq Analysis of KRAS Mutant HPNE Pancreatic Ductal Epithelial Cells 66 samples shares kras, pancreatic
- GSE295260 CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation 40 samples shares cdk4, induces
- GSE303051 Prolonged KRAS-MAPK Inhibition Induces Interferon-mediated Epithelial-to-Mesenchymal Transition and Reveals Therapeutic Opportunities. 30 samples shares kras, induces
- GSE316970 CYD-4-61 Suppresses Gastric Tumor Growth by Targeting SOX9–CDK4–Driven Oncogenic Programs and Enhances Anti-PD-1 Therapy 18 samples shares cdk4, targeting
- GSE310675 CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer 12 samples shares kras, pancreatic
- GSE300083 The Lysine Demethylase Kdm4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma [RNA-Seq] 12 samples shares kras, pancreatic
- GSE309499 HDAC5 Deficiency Induces Intrinsic Resistance to KRASG12D Inhibition by Disrupting c-Myc Acetylation-Ubiquitination Homeostasis [RNA-seq] 12 samples shares kras, induces
- GSE295258 CDK4/6 inhibition induces a senescence-associated secretory phenotype via delayed NF-κB activation 54 samples shares cdk4, induces
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.