← BioTransfer GEO Dataset Finder
GEO series

SWAP70 Promotes Atherosclerosis via Endothelial CAV1 Nuclear Translocation [ATAC-seq]

GSE301155 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2026/01/08 Platform GPL34284
Summary
Hemodynamic forces play a pivotal role in modulating endothelial function and contribute to the spatial distribution of atherosclerotic lesions. Here, we identify SWAP70 as a flow-sensitive gene whose chromatin accessibility is dynamically regulated by shear stress. Using ATAC-seq analysis of human endothelial cells exposed to static conditions, laminar shear stress (LSS), or oscillatory shear stress (OSS) for 72 hours, we observed that OSS markedly increased chromatin accessibility at the SWAP70 promoter compared to LSS. This enhanced accessibility under OSS suggests transcriptional activation of SWAP70 in response to disturbed flow. These findings indicate that SWAP70 may serve as a mechanosensitive regulator, epigenetically primed by atheroprone flow patterns to modulate endothelial inflammation.
Published in
SWAP70 Promotes Atherosclerosis Via Endothelial CAV1 Nuclear Translocation
Gao T, Li X, Zhang W et al. · Circulation research 2026 · PMID 41532295 · doi:10.1161/CIRCRESAHA.125.327048
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE301155_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1284207 and SRA study SRP596264. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.