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PURPL plays a role in epigenetic regulation of gene expression [ChIP-Seq]

GSE301169 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/12/02 Platform GPL29480
Summary
Cellular senescence involves heterochromatin reorganization and aberrant gene expression. We demonstrate that the nuclear-enriched lncRNA PURPL regulates senescence-associated chromatin dynamics by modulating H3K9me3 deposition. PURPL knockdown increased global H3K9me3 levels while its overexpression reduced this repressive mark. Genome-wide analysis revealed 411 loci with PURPL-dependent H3K9me3 changes, including the aging-related gene SERPINE1, where H3K9me3 accumulation correlated with transcriptional repression. These findings establish PURPL as an epigenetic regulator of senescence through targeted control of heterochromatin formation.
Published in
Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming
Wang J, Yang X, Su X et al. · Journal of translational medicine 2025 · PMID 41107828 · doi:10.1186/s12967-025-07208-5
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Also filed as BioProject PRJNA1284216 and SRA study SRP596228. Searching any of these in the dataset finder brings you back here.

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