TopBP1 controls conventional dendritic cell development and Flt3L-driven cDC1 differentiation via PU.1 and IRF8 [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 2 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TopBP1 orchestrates PU.1-IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunityExperimental & molecular medicine · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE301438_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1285171 and SRA study SRP597333. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE300836 TopBP1 controls conventional dendritic cell development and Flt3L-driven cDC1 differentiation via PU.1 and IRF8 4 samples shares topbp1, cdc1, irf8, conventional, flt3l-driven, dendritic, controls
- GSE271282 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (RNA-seq of IRF8 KO HoxB8-FL DCs) 6 samples shares irf8, conventional, dendritic, controls
- GSE277289 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (RAD21 and CTCF ChIP-seq of Hoxb8-FL differentiation) 9 samples shares conventional, dendritic, controls, chip-seq
- GSE270819 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (CUT&RUN of FL-BMDCs and HoxB8-FL progenitors) 20 samples shares conventional, dendritic, controls
- GSE312958 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (H3K27me3 CUT&RUN of SMC3KO FL-BMDCs +/- activation) 6 samples shares conventional, dendritic, controls
- GSE271283 Cohesin-mediated chromatin remodeling controls the differentiation and function of conventional dendritic cells (RNA-seq of SMC3 KO splenic cDCs) 16 samples shares conventional, dendritic, controls
- GSE315388 A20 stabilizes IRF8: De novo trogocytic cDC2s orchestrate robust anti-tumor immunity in cDC1-deficient A20cKO mice 9 samples shares cdc1, irf8
- GSE299049 A20 stabilizes IRF8: De novo trogocytic cDC2s orchestrate robust anti-tumor immunity in cDC1-deficient A20cKO mice 9 samples shares cdc1, irf8
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.