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Limited response of primary nasal epithelial cells to Bordetella pertussis infection [RNAseq_Sort_population]

GSE302040 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/22 Platform GPL18573
Summary
Bordetella pertussis is a Gram-negative coccobacillus that causes whooping cough or pertussis, a respiratory disease that has recently experienced a resurgence. Upon entering the respiratory tract, B. pertussis colonizes the airway epithelium and attaches to ciliated cells. Here, we used primary human nasal epithelial cells (hNECs) cultured at the air-liquid interface, and investigated their transcriptomic response after infection with the B. pertussis B1917. We also analyzed role of the type III secretion system effector protein BteA in modulating this response.
Published in
Limited response of primary nasal epithelial cells to Bordetella pertussis infection
Zmuda M, Malcova I, Pravdova B et al. · Microbiology spectrum 2025 · PMID 40757824 · doi:10.1128/spectrum.01267-25
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Also filed as BioProject PRJNA1216212 and SRA study SRP560124. Searching any of these in the dataset finder brings you back here.

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