Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoids
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Breast cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 2 × Patient 409 PDOs, control, vs 2 × Patient 409 PDOs, nondiabetic exosome treated, vs 2 × Patient 409 PDOs, type 2 diabetic exosome treated,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Plasma exosomes from individuals with type 2 diabetes drive breast cancer aggression in patient-derived organoidsCommunications biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302054_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1288430 and SRA study SRP599161. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9095088 Patient 318 PDOs, control
- GSM9095089 Patient 318 PDOs, nondiabetic exosome treated
- GSM9095090 Patient 318 PDOs, type 2 diabetic exosome treated
- GSM9095091 Patient 377 PDOs, control
- GSM9095092 Patient 377 PDOs, nondiabetic exosome treated
- GSM9095093 Patient 377 PDOs, type 2 diabetic exosome treated
- GSM9095094 Patient 409 PDOs, control, biological replicate 1 Patient 409 PDOs, contr…
- GSM9095095 Patient 409 PDOs, nondiabetic exosome treated, biological replicate 1 Patient 409 PDOs, nondi…
- GSM9095096 Patient 409 PDOs, type 2 diabetic exosome treated, biological replicate 1 Patient 409 PDOs, type …
- GSM9095097 Patient 409 PDOs, control, biological replicate 2 Patient 409 PDOs, contr…
- GSM9095098 Patient 409 PDOs, nondiabetic exosome treated, biological replicate 2 Patient 409 PDOs, nondi…
- GSM9095099 Patient 409 PDOs, type 2 diabetic exosome treated, biological replicate 2 Patient 409 PDOs, type …
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.