GEO series
GLI2 mediates response to paclitaxel in triple-negative breast cancer
GSE302168
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/07/08
GPL24676
Summary
Bone is the most frequent site of both metastasis and recurrence for patients with breast cancer, and there are currently no FDA-approved therapeutics which target cancer in bone. Skeletal metastases upregulate the transcription factor Glioma-associated oncogene 2 (Gli2), resulting in secretion of parathyroid hormone-related protein (PTHrP), which accelerates bone turnover and enables tumor proliferation. Gli2 has been implicated as a mediator of chemoresistance in a wide range of cancers, but its unique role in drug resistance has yet to be defined in treatment-resistant skeletal metastases. Therefore, this dataset aims to define the impact of GLI2 CRISPR knockout on transcriptional response to paclitaxel (PTX), the current standard of care for breast cancer patients with distant metastases.
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