Co-targeting EZH2 and TEAD elicits apoptosis through tumor-intrinsic innate immune signaling in Hippo pathway-mutated cancers - ChIP-seq data from genetic disruption of EZH2
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 41 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 41 samples: 19 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302321_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1289864 and SRA study SRP599983. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 40 samples.
How we read this: 19 replicated groups read from 41 sample titles; they account for 40 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9101828 Control DMSO H3K27Ac Rep1 Control DMSO H3K27Ac
- GSM9101829 Control DMSO H3K27Ac Rep2 Control DMSO H3K27Ac
- GSM9101830 Control MYF H3K27Ac Rep1 Control MYF H3K27Ac
- GSM9101831 Control MYF H3K27Ac Rep2 Control MYF H3K27Ac
- GSM9101832 KO DMSO H3K27Ac Rep1 KO DMSO H3K27Ac
- GSM9101833 KO DMSO H3K27Ac Rep2 KO DMSO H3K27Ac
- GSM9101834 KO MYF H3K27Ac Rep1 KO MYF H3K27Ac
- GSM9101835 KO MYF H3K27Ac Rep2 KO MYF H3K27Ac
- GSM9101836 Control DMSO H3K27me3 Rep1 Control DMSO H3K27me3
- GSM9101837 Control DMSO H3K27me3 Rep2 Control DMSO H3K27me3
- GSM9101838 Control MYF H3K27me3 Rep2
- GSM9101839 KO DMSO H3K27me3 Rep1 KO DMSO H3K27me3
- GSM9101840 KO DMSO H3K27me3 Rep2 KO DMSO H3K27me3
- GSM9101841 KO MYF H3K27me3 Rep1 KO MYF H3K27me3
- GSM9101842 KO MYF H3K27me3 Rep2 KO MYF H3K27me3
- GSM9101843 Control DMSO TEAD4 Rep1 Control DMSO TEAD4
- GSM9101844 Control DMSO TEAD4 Rep2 Control DMSO TEAD4
- GSM9101845 Control Myf TEAD4 Rep1 Control Myf TEAD4
- GSM9101846 Control Myf TEAD4 Rep2 Control Myf TEAD4
- GSM9101847 KO DMSO TEAD4 Rep1 KO DMSO TEAD4
- GSM9101848 KO DMSO TEAD4 Rep2 KO DMSO TEAD4
- GSM9101849 KO Myf TEAD4 Rep1 KO Myf TEAD4
- GSM9101850 KO Myf TEAD4 Rep2 KO Myf TEAD4
- GSM9101851 SF DMSO H3K27Ac Rep1 SF DMSO H3K27Ac
- GSM9101852 SF DMSO H3K27Ac Rep2 SF DMSO H3K27Ac
- GSM9101853 SF TAZ H3K27Ac Rep1 SF TAZ H3K27Ac
- GSM9101854 SF TAZ H3K27Ac Rep2 SF TAZ H3K27Ac
- GSM9101855 SF MYF H3K27Ac Rep1 SF MYF H3K27Ac
- GSM9101856 SF MYF H3K27Ac Rep2 SF MYF H3K27Ac
- GSM9101857 SF DMSO H3K27me3 Rep1 SF DMSO H3K27me3
- GSM9101858 SF DMSO H3K27me3 Rep2 SF DMSO H3K27me3
- GSM9101859 SF TAZ H3K27me3 Rep1 SF TAZ H3K27me3
- GSM9101860 SF TAZ H3K27me3 Rep2 SF TAZ H3K27me3
- GSM9101861 SF TAZMYF H3K27me3 Rep1 SF TAZMYF H3K27me3
- GSM9101862 SF TAZMYF H3K27me3 Rep2 SF TAZMYF H3K27me3
- GSM9101863 Control DMSO TEAD4 Rep3 Control DMSO TEAD4
- GSM9101864 Control DMSO TEAD4 Rep4 Control DMSO TEAD4
- GSM9101865 Control TAZ TEAD4 Rep3 Control TAZ TEAD4
- GSM9101866 Control TAZ TEAD4 Rep4 Control TAZ TEAD4
- GSM9101867 Control TAZMYF TEAD4 Rep3 Control TAZMYF TEAD4
+ 1 more — browse all 41 samples with per-sample file links →
- GSE301957 Co-targeting EZH2 and TEAD elicits apoptosis through tumor-intrinsic innate immune signaling in Hippo pathway-mutated cancers - RNA-seq data from genetic disruption of EZH2 12 samples shares ezh2, tead, tumor-intrinsic, pathway-mutated, co-targeting, disruption, apoptosis
- GSE330470 ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [ChIP-seq] 55 samples shares tead, chip-seq
- GSE330469 ChIP-seq and CUT&Tag profiling of the genome binding of YAP/TAZ-TEAD and SMAD3 in the human HCC cell line HCCLM3 [CUT&Tag] 24 samples shares tead, chip-seq
- GSE301506 YAP AND TEAD ARE TRANSCRIPTIONAL REGULATORS OF NEUROENDOCRINE DIFFERENTIATION AND GROWTH IN CARCINOID CELLS [ChIP-seq] 20 samples shares tead, chip-seq
- GSE193481 Super-silencer perturbation by EZH2 and REST inhibition leads to large loss of chromatin interactions and reduction in cancer growth [ChIP-seq] 18 samples shares ezh2, chip-seq
- GSE242500 Epigenetic modifiers MMSET and EZH2 physically interact and cooperate to support Multiple Myeloma pathophysiology [ChIP-seq] 16 samples shares ezh2, chip-seq
- GSE262487 UBR7 in concert with EZH2 inhibits the TGF-β signalling leading to extracellular matrix remodelling [ChIP-seq] 14 samples shares ezh2, chip-seq
- GSE208685 Adenovirus small E1A directs activation of Alu transcription at YAP/TEAD- and AP-1- bound enhancers through interactions with the EP400 chromatin remodeler [ChIP-Seq] 12 samples shares tead, chip-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.