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Single-cell RNA Sequencing Analysis Reveals Cell Landscape and Gene Signatures Associated with Granulomatous Lobular Mastitis

GSE302333 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/14 Platform GPL24676
Summary
We have employed a single cell sequencing approach using 10x Genomics scRNAseq to study granulomatous lobular mastitis (GLM), a chronic inflammatory breast disease characterized by granuloma formation and recurrent abscesses. GLM is considered an immune-mediated disorder, yet its underlying pathogenesis remains poorly defined. This study is the first to perform single-cell transcriptomic profiling of GLM tissue and provides new insights into the cellular landscape and immune dysregulation associated with GLM.
Published in
Single-cell RNA sequencing analysis reveals cell landscape and gene signatures associated with granulomatous lobular mastitis
Wang J, Zeng Y, Wang M et al. · Frontiers in immunology 2025 · PMID 41181111 · doi:10.3389/fimmu.2025.1624640
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Also filed as BioProject PRJNA1290103 and SRA study SRP600070. Searching any of these in the dataset finder brings you back here.

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