GEO series
CAR T Cell Sytotoxic Supernatant Stimulates Monocytes to Drive Cytokine Storm
GSE302543
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/07/20
GPL24676
Summary
Chimeric antigen receptor (CAR) T cell-therapy is substantially constrained by cytokine release syndrome (CRS). The precise mechanisms underlying CAR T cell-therapy-associated CRS remain elusive. Here, we show that CAR T cell-induced tumor cytotoxicity activates monocytes to release IL-1β, IL-6, and TNF-α, key inflammatory cytokines driving CRS, via monocyte contact-independent manner.
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