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Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin [Cut & Tag]

GSE302552 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2025/07/18 Platform GPL16417
Summary
This study aimed to investigate epigenetic regulation in murine aortic valves by profiling H3K27ac enrichment in control and Hdac3-deficient valves, as well as HDAC3 and phosphorylated HDAC3 (Ser424) occupancy in control valves. Using CUT&Tag, we assessed genome-wide changes in enhancer activity and HDAC3 binding to identify regulatory elements and pathways disrupted by Hdac3 deletion in valvular interstitial cells. These data provide insight into the role of HDAC3 and its phosphorylation in maintaining epigenetic homeostasis and gene expression programs critical for aortic valve integrity.
Published in
Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin
Cashman TJ, Saheera S, Blau AE et al. · JCI insight 2025 · PMID 40923319 · doi:10.1172/jci.insight.188562
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Direct links to NCBI, no account and no request form: the whole study as GSE302552_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 5 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1291176 and SRA study SRP600821. Searching any of these in the dataset finder brings you back here.

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