Gasdermin E is Dispensable for H1N1 Influenza Virus Pathogenesis in Mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × GSDME_KO_PR8 vs 3 × WT_PR8 vs 3 × GSDME_KO_mock vs 3 × WT_mockGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in miceMicrobiology spectrum · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302673_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1291709 and SRA study SRP600914. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9108572 GSDME_KO_PR8_1 GSDME_KO_PR8
- GSM9108573 GSDME_KO_PR8_2 GSDME_KO_PR8
- GSM9108574 GSDME_KO_PR8_3 GSDME_KO_PR8
- GSM9108575 WT_PR8_1 WT_PR8
- GSM9108576 WT_PR8_2 WT_PR8
- GSM9108577 WT_PR8_3 WT_PR8
- GSM9108578 GSDME_KO_mock_1 GSDME_KO_mock
- GSM9108579 GSDME_KO_mock_2 GSDME_KO_mock
- GSM9108580 GSDME_KO_mock_3 GSDME_KO_mock
- GSM9108581 WT_mock_1 WT_mock
- GSM9108582 WT_mock_2 WT_mock
- GSM9108583 WT_mock_3 WT_mock
- GSE294560 Bulk RNAseq profiling of Streptococcus pneumoniae EF3030 and Influenza A virus (A/California/07/2009(H1N1)) mono/coinfection in the mouse lungs. 60 samples shares h1n1, influenza, virus
- GSE32602 Distal airway stem cells yield alveoli in vitro and during lung regeneration following H1N1 influenza infection (LCM_Four populations of cells) 12 samples shares h1n1, influenza
- GSE281057 Mitochondrial dysfunction enhances influenza pathogenesis by upregulating sialic acid biosynthesis 29 samples shares pathogenesis, influenza
- GSE223673 Nr5a2 is dispensable for ZGA but essential for morula development [RNA-seq] 514 samples shares dispensable
- GSE296707 Neuromuscular junction transcriptome analysis of spinal and bulbar muscular atrophy mice implicates sarcomere gene expression and calcium flux dysregulation in disease pathogenesis 30 samples shares pathogenesis
- GSE308110 Transcriptomic profiling of brain tissues from HIV-1 gp120 transgenic mice reveals insights into neuropathogenesis 10 samples shares pathogenesis
- GSE235751 Cardiac Transcriptomic Changes Induced by Early CKD in Mice Reveal Novel Pathways Involved in the Pathogenesis of Cardiorenal Syndrome Type 4 9 samples shares pathogenesis
- GSE275608 Phosphorylation of PLIN5 is dynamically regulated in mice, required for IRS2 expression in the male mice liver, but dispensable for PGC1a target genes previously associated with PLIN5 8 samples shares dispensable
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.