Single-Cell RNA Sequencing Unravels Interactions between Macrophages and Fibroadipogenic Progenitors during Ectopic Bone Formation in FOP Mice
Single-cell RNA-seq · mouse · 12 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × skeletal muscle cells WT, at 5 days after induced damage vs 3 × skeletal muscle cells MUT, at 5 days after induced damage vs 3 × skeletal muscle cells WT, at 7 days after induced damage vs 3 × skeletal muscle cells MUT, at 7 days after induced damageGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalkCellular and molecular life sciences : CMLS · 2026
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE302734_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1291819 and SRA study SRP600999. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9110436 skeletal muscle cells WT, at 5 days after induced damage. biological replicate 1 skeletal muscle cells W…
- GSM9110437 skeletal muscle cells WT, at 5 days after induced damage. biological replicate 2 skeletal muscle cells W…
- GSM9110438 skeletal muscle cells WT, at 5 days after induced damage. biological replicate 3 skeletal muscle cells W…
- GSM9110439 skeletal muscle cells MUT, at 5 days after induced damage. biological replicate 1 skeletal muscle cells M…
- GSM9110440 skeletal muscle cells MUT, at 5 days after induced damage. biological replicate 2 skeletal muscle cells M…
- GSM9110441 skeletal muscle cells MUT, at 5 days after induced damage. biological replicate 3 skeletal muscle cells M…
- GSM9110442 skeletal muscle cells WT, at 7 days after induced damage. biological replicate 1 skeletal muscle cells W…
- GSM9110443 skeletal muscle cells WT, at 7 days after induced damage. biological replicate 2 skeletal muscle cells W…
- GSM9110444 skeletal muscle cells WT, at 7 days after induced damage. biological replicate 3 skeletal muscle cells W…
- GSM9110445 skeletal muscle cells MUT, at 7 days after induced damage. biological replicate 1 skeletal muscle cells M…
- GSM9110446 skeletal muscle cells MUT, at 7 days after induced damage. biological replicate 2 skeletal muscle cells M…
- GSM9110447 skeletal muscle cells MUT, at 7 days after induced damage. biological replicate 3 skeletal muscle cells M…
- GSE239287 Single-cell transcriptome sequencing of macrophages in acute kidney injury(AKI) to chronic kidney dieases(CKD) 17 samples shares single-cell, macrophages
- GSE264607 Molecular targets of colorectal cancer transformation revealed by single-cell sequencing 14 samples shares single-cell, formation
- GSE192687 Single-cell RNAseq analysis of renal endothelial cells in murine diabetic nephropathy 5464 samples shares single-cell
- GSE277789 Spatiotemporal and genetic cell lineage tracing of endodermal organogenesis at single-cell resolution [Smart-seq3-RNA-seq-add] 830 samples shares single-cell
- GSE290574 Gene Regulatory Networks Orchestrating Oocyte Fate Bifurcation in Primordial Follicles Revealed by Single-Cell Transcriptomics 386 samples shares single-cell
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares single-cell
- GSE239602 Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during murine atherosclerosis 82 samples shares single-cell
- GSE278990 Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity 73 samples shares single-cell
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.