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Effect of knockdown of miR-BART19-3p on gene expression of AGS EBV cells

GSE302909 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/22 Platform GPL28038
Summary
EBV microRNAs, especially rightward transcript (BART) microRNAs play key roles in the tumor growth of EBVaGC. However, the effects of EBV-miR-BART19-3p in EBVaGC remain largely unknown. Here, we report that EBV-miR-BART19-3p is highly expressed in EBVaGC and promoted the proliferation of EBV-associated gastric cancer cells in vitro and accelerate xenograft tumor growth in vivo. Molecularly, EBV-miR-BART19-3p directly targets the growth arrest and DNA damage-inducing protein Beta mRNA (GADD45B) and downregulates its protein expression, which consequently reduce cell cycle G2/M phase arrest. Reconstitution of GADD45B can rescue the proliferation phenotype caused by EBV-miR-BART19-3p in EBVaGC cells, highlighting the role of GADD45B in EBV-miR-BART-driven Gastric cancer. Our study indicated Epstein-Barr Virus MicroRNA BART19-3p played an oncogenic role by a novel mechanism of inhibiting GADD45B in EBVaGC, which provides new insights and might be a potential therapeutic strategy for EBVaGC patients.
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Also filed as BioProject PRJNA1292806 and SRA study SRP601555. Searching any of these in the dataset finder brings you back here.

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