GEO series
iPSc-to-thymic epithelial progenitor differentiation under multifactorial DoE optimization and transcriptomic profiling
GSE302942
Homo sapiens
Expression profiling by high throughput sequencing
96 samples
2025/11/21
GPL24676
Summary
This study investigates the differentiation of human induced pluripotent stem cells (iPSc) into thymic epithelial progenitors (TEPs) through a combinatorial experimental design (Design of Experiments, DoE). Bulk RNA-seq was performed across 96 differentiation conditions covering key developmental transitions: definitive endoderm (DE), anterior foregut endoderm (AFE), third pharyngeal pouch endoderm (3PPE), and thymic epithelial progenitors (TEP). The multifactorial screen leveraged Plackett-Burman designs and transcriptomic similarity to in vivo pharyngeal development atlases to identify optimal differentiation cues.
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Paper (PMID 41577697) ↗
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