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HNRNPH controls alternative splicing cooperatively on a transcriptome-wide scale

GSE303138 synthetic construct; Homo sapiens RNA-seq (gene expression) 63 samples Submitted 2026/04/14 Platform GPL18573Platform GPL19424
At a glance

RNA-seq (gene expression) · synthetic construct; Homo sapiens · 63 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
synthetic construct; Homo sapiens
Samples
63 samples: 43 distinct titles, 7 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
RNA G-quadruplexes mediate cooperativity in HNRNPH binding and splicing regulationbioRxiv : the preprint server for biology · 2026
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
RNA G-quadruplexes mediate cooperativity in HNRNPH binding and splicing regulation
Tretow K, Keller M, Mesitov M et al. · bioRxiv : the preprint server for biology 2026 · PMID 41867855 · doi:10.64898/2026.03.03.709289
This dataset
Open GSE303138 in finder → Find more datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303138_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1294208 and SRA study SRP607643. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41867855) ↗
Study design
43 distinct titles, 7 of them repeated
iCLIP, MCF7, HNRNPH immunoprecipitation, ×7 in vitro iCLIP, RNA oligo library, GTP RNA, ×4 in vitro iCLIP, RNA oligo library, 7-deaza-GT… ×4 RT-Stop Profiling, RNA oligo library, GTP, KC… ×3 RT-Stop Profiling, RNA oligo library, GTP, Na… ×3 RT-Stop Profiling, RNA oligo library, 7-deaza… ×3 RT-Stop Profiling, RNA oligo library, 7-deaza… ×3

How we read this: Read from 63 sample titles: 43 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study

+ 23 more — browse all 63 samples with per-sample file links →

Datasets on a similar topic

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.