Anthracyclines induce global changes in chromatin accessibility in cardiomyocytes that overlap with cardiovascular disease loci
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 2 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 2 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Anthracyclines induce global changes in cardiomyocyte chromatin accessibility that overlap with cardiovascular disease lociPLoS genetics · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303207_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1294343 and SRA study SRP602419. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 2 more — browse all 2 samples with per-sample file links →
- GSE285390 Incorporating histone H2B variants into chromatin modifies chromatin accessibility to induce the epithelial-to-mesenchymal transition in breast cancer [CUT&RUN] 32 samples shares accessibility, chromatin, induce
- GSE269112 Notch induces transcription by stimulating release of paused RNA Pol II without increasing chromatin accessibility [ATAC-seq] 28 samples shares accessibility, chromatin, induce
- GSE240183 HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype [ATAC-seq] 22 samples shares accessibility, chromatin, changes
- GSE309352 Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice [ChIP-Seq] 14 samples shares accessibility, chromatin, changes
- GSE290342 Caloric restriction mimetic 2-deoxyglucose alters metabolic and transcriptomic phenotype in association with changes in chromatin accessibility in human astrocytes [ATAC-Seq] 12 samples shares accessibility, chromatin, changes
- GSE178494 Chromatin accessibility and transcriptomic changes underlying progression from islet autoantibody positivity to type 1 diabetes 89 samples shares accessibility, chromatin, changes
- GSE324655 Transcriptional and chromatin accessibility profiling of melanoma cells during BRAF inhibitor–induced drug tolerance 31 samples shares accessibility, chromatin, induce
- GSE309354 Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice [multiome] 24 samples shares accessibility, chromatin, changes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.