← BioTransfer GEO Dataset Finder
GEO series

The PARP Inhibitor Talazoparib efficiently Suppresses Tumor Growth in Castration-Resistant Prostate Cancer

GSE303244 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/07/31 Platform GPL24676
Summary
To address the limited understanding of PARP inhibitor monotherapy in castration-resistant prostate cancer (CRPC), we investigated the antitumor effects of Talazoparib in CRPC cells with homologous recombination repair (HRR) gene mutations. We treated DU 145 and PC-3 cells with Talazoparib and observed reduced proliferation, migration, and colony formation. Western blot analysis showed increased apoptosis and DNA damage. RNA sequencing revealed downregulation of key HRR genes (BRCA1/2, ATM, ATR), and gene set enrichment analysis confirmed suppression of DNA repair pathways and activation of immune-related responses. These findings suggest that Talazoparib not only exploits synthetic lethality but also impairs HRR gene expression, supporting its potential as monotherapy in HRR-deficient CRPC.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE303244_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1294391 and SRA study SRP602456. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.