GEO series
Chromatin Accessibility Dynamics Suggest Immune-Modulatory Effects of Vitamin D3 In Vivo
GSE303320
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
76 samples
2025/12/30
GPL18573
Summary
Vitamin D₃ is a key micronutrient known to support innate immunity and modulate adaptive responses, with in vitro studies suggesting the involvement of epigenetic mechanisms. However, in vivo evidence remains limited. In this study, we investigated genome-wide epigenomic responses to vitamin D₃ supplementation in a cohort of 38 individuals from a Polish population. Peripheral blood mononuclear cells (PBMCs) were collected at baseline (day 0) and 24 hours after supplementation (day 1). ATAC-seq analyses revealed widespread vitamin D₃-induced changes in chromatin accessibility.
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Paper (PMID 41413700) ↗
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