← BioTransfer GEO Dataset Finder
GEO series

Gene expression in Tetrahydrocurcumin-treated HUVEC cells

GSE303488 Homo sapiens Expression profiling by high throughput sequencing 3 samples Submitted 2026/02/24 Platform GPL20301
Summary
Endothelial nitric oxide synthase (eNOS) plays a crucial role in maintaining endothelial cell function and preventing atherosclerosis. Tetrahydrocannabinol is a metabolite that has better bioactivity than curcumin. This study investigated the effect of the PI3K/AKTpathway on eNOS expression and NO production induced by tetrahydrocannabinol (THCu) in human umbilical vein endothelial cells. The findings reveal that both PI3Kand AKT are essential for THC-induced eNOS phosphorylation and subsequent NO production.
Published in
Elucidating the vasoprotective mechanism of Tetrahydrocurcumin: from unbiased transcriptomic discovery to targeted validation of the PI3K/AKT pathway
Chiu YL, Lin TJ, Lai HF et al. · BMC complementary medicine and therapies 2026 · PMID 41963969 · doi:10.1186/s12906-026-05326-1
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE303488_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 3 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1295509 and SRA study SRP603115. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 3 more — browse all 3 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.