EZH2 directs breast cancer progression through the modulation of epithelial cellular plasticity [ChIP-Seq]
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 16 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 16 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- EZH2 directs HER2+ breast cancer progression through the modulation of epithelial plasticityEMBO reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303502_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1295532 and SRA study SRP603138. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 16 sample titles: 16 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9128146 Mouse tumor, EZH2knockout, biol rep1 (H3K27me3 ChIP)
- GSM9128147 Mouse tumor, EZH2knockout, biol rep2 (H3K27me3 ChIP)
- GSM9128148 Mouse tumor, EZH2wildtype, biol rep1 (H3K27me3 ChIP)
- GSM9128149 Mouse tumor, EZH2wildtype, biol rep2 (H3K27me3 ChIP)
- GSM9128150 Mouse tumor, EZH2knockout, biol rep1 (Input)
- GSM9128151 Mouse tumor, EZH2knockout, biol rep2 (Input)
- GSM9128152 Mouse tumor, EZH2wildtype, biol rep1 (Input)
- GSM9128153 Mouse tumor, EZH2wildtype, biol rep2 (Input)
- GSM9128154 SKBR3 human breast cancer cell line,DMSO, rep1 (H3K27me3 ChIP)
- GSM9128155 SKBR3 human breast cancer cell line,DMSO, rep2 (H3K27me3 ChIP)
- GSM9128156 SKBR3 human breast cancer cell line, EPZ6438, rep1 (H3K72me3 ChIP)
- GSM9128157 SKBR3 human breast cancer cell line, EPZ6438, rep2 (H3K27me3 ChIP)
- GSM9128158 SKBR3 human breast cancer cell line,DMSO, rep1 (Input)
- GSM9128159 SKBR3 human breast cancer cell line,DMSO, rep2 (Input)
- GSM9128160 SKBR3 human breast cancer cell line, EPZ6438, rep1 (Input)
- GSM9128161 SKBR3 human breast cancer cell line, EPZ6438, rep2 (Input)
- GSE262919 EZH2 deletion does not impact acinar cell regeneration but restricts progression to pancreatic cancer in mice [ChIP-seq] 36 samples shares ezh2, progression, chip-seq
- GSE297048 EZH2 alters aggressive variant prostate cancer subtype evolution, but is not required for neuroendocrine prostate cancer [ChIP-seq] 40 samples shares ezh2, chip-seq
- GSE250574 CCN6/WISP3 suppresses metaplastic breast carcinoma by antagonizing a WNT/b-catenin/EZH2 cascade [ChIP-seq] 16 samples shares ezh2, chip-seq
- GSE275917 Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation [ChIP-seq] 17 samples shares modulation, chip-seq
- GSE248586 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma 57 samples shares progression, epithelial
- GSE241850 Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer progression via extracellular vesicle transfer of m6A-modified RNAs 57 samples shares progression, cellular
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares progression, epithelial
- GSE287625 Mitochondrial Ca2+ controls pancreatic cancer growth and metastasis by regulating epithelial cell plasticity 18 samples shares epithelial, plasticity
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.