ISL1: A Novel Neuroendocrine Subtype in Small Cell Lung Cancer Predicts Durable Response to Lurbinectedin
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ISL1: A Novel Neuroendocrine Subtype in Small Cell Lung Cancer Predicts Durable Response to LurbinectedinMolecular cancer therapeutics · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE303770_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1294959 and SRA study SRP603452. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9135671 H187 DMSO 1 H187 DMSO
- GSM9135672 H187 DMSO 2 H187 DMSO
- GSM9135673 H187 DMSO 3 H187 DMSO
- GSM9135674 H187 Lurbi 1 H187 Lurbi
- GSM9135675 H187 Lurbi 2 H187 Lurbi
- GSM9135676 H187 Lurbi 3 H187 Lurbi
- GSM9135677 H209 DMSO 1 H209 DMSO
- GSM9135678 H209 DMSO 2 H209 DMSO
- GSM9135679 H209 DMSO 3 H209 DMSO
- GSM9135680 H209 Lurbi 1 H209 Lurbi
- GSM9135681 H209 Lurbi 2 H209 Lurbi
- GSM9135682 H209 Lurbi 3 H209 Lurbi
- GSM9135683 H82 DMSO 1 H82 DMSO
- GSM9135684 H82 DMSO 2 H82 DMSO
- GSM9135685 H82 DMSO 3 H82 DMSO
- GSM9135686 H82 Lurbi 1 H82 Lurbi
- GSM9135687 H82 Lurbi 2 H82 Lurbi
- GSM9135688 H82 Lurbi 3 H82 Lurbi
- GSM9135689 SHP-77 DMSO 1 SHP-77 DMSO
- GSM9135690 SHP-77 DMSO 2 SHP-77 DMSO
- GSM9135691 SHP-77 DMSO 3 SHP-77 DMSO
- GSM9135692 SHP-77 Lurbi 1 SHP-77 Lurbi
- GSM9135693 SHP-77 Lurbi 2 SHP-77 Lurbi
- GSM9135694 SHP-77 Lurbi 3 SHP-77 Lurbi
- GSE303043 UHRF1 drives subtype-independent aggressiveness and immune evasion in small cell lung cancer through GATA2-ST6GALNAC5 and PRC2 interactions 30 samples same disease briefing · shares subtype, small, lung
- GSE280219 ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer. 24 samples same disease briefing · shares neuroendocrine, small, lung
- GSE274458 Crosstalk between cancer-associated fibroblasts and non-neuroendocrine tumor cells in small cell lung cancer involves in glycolysis and antigen-presenting features 15 samples same disease briefing · shares neuroendocrine, small, lung
- GSE256347 SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing [RNA-seq] 13 samples same disease briefing · shares neuroendocrine, small, lung
- GSE267310 Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities 12 samples same disease briefing · shares neuroendocrine, small, lung
- GSE255757 Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells 6 samples same disease briefing · shares neuroendocrine, small, lung
- GSE255825 Formation of malignant, metastatic small cell lung cancers through overproduction of cMYC protein in TP53 and RB1 depleted pulmonary neuroendocrine cells derived from human embryonic stem cells [bulk RNA-seq] 5 samples same disease briefing · shares neuroendocrine, small, lung
- GSE244123 Olfactory neuroblastoma mimics molecular subtypes and lineage trajectories of small cell lung cancer 103 samples same disease briefing · shares subtype, small, lung
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.