GEO series
Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation_cuttag seq
GSE303850
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
12 samples
2025/12/10
GPL24676
Summary
Rationale: Endothelial cell senescence leads to endothelial dysfunction, thereby promoting the progression of atherosclerosis. Super-enhancers are crucial epigenetic cis-regulatory elements whose extensive reprogramming drives aberrant transcription in human diseases. However, the underlying mechanisms of super-enhancer on endothelial cell senescence remain unclear.
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Paper (PMID 41355963) ↗
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