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Single-cell RNA-Seq Analysis of the Long-Term engrafting HSPC in NSG and NBSGW models.

GSE303930 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/05/27 Platform GPL24676
Summary
single cell (sc)-RNA-sequencing was used to characterize transcriptional differences of the human CD34+ HSPC engrafted in the NSG vs. the NBSGW mouse models after gene correction by CRISPR/Cas9 and a single stranded oligonucleotide (ssODN)
Published in
Comparative analysis of NSG and NBSGW mice for preclinical evaluation of gene-modified human hematopoietic stem and progenitor cells
Kuo CY, Harrington S, Campo-Fernandez B et al. · Stem cell research & therapy 2026 · PMID 41987334 · doi:10.1186/s13287-026-05010-8
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Also filed as BioProject PRJNA1298251 and SRA study SRP604300. Searching any of these in the dataset finder brings you back here.

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