DNA methylation profiling identifies long-range epigenetic silencing of clustered protocadherins as a key determinant of meningioma progression
DNA methylation · human · 293 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 293 samples: 289 × T26Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304097_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1298904 and SRA study SRP604646. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 289 samples.
How we read this: 1 replicated groups read from 299 sample titles; they account for 289 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9142967 T26_0094 T26
- GSM9142968 T26_0097 T26
- GSM9142969 T26_0061 T26
- GSM9142970 T26_0016 T26
- GSM9142971 T26_0103 T26
- GSM9142972 T26_0076 T26
- GSM9142973 T26_0175 T26
- GSM9142974 T26_0072 T26
- GSM9142975 T26_0058 T26
- GSM9142976 T26_0123 T26
- GSM9143061 IOMM_Lee_REP_A
- GSM9143062 IOMM_Lee_REP_B
- GSM9143063 BEN-MEN-1_REP_A
- GSM9143064 BEN-MEN-1_REP_B
- GSM9143065 HBL-52_REP_A
- GSM9143066 HBL-52_REP_B
- GSM9143067 KT21-MG1_REP_A
- GSM9143068 KT21-MG1_REP_B
- GSM9143069 NCH93_REP_A
- GSM9143070 NCH93_REP_B
- GSM9143071 T26_0053 T26
- GSM9143072 T26_0137 T26
- GSM9143073 T26_0144 T26
- GSM9143074 T26_0193 T26
- GSM9143075 T26_0119 T26
- GSM9143076 T26_0028 T26
- GSM9143077 T26_0015 T26
- GSM9143078 T26_0191 T26
- GSM9143079 T26_0071 T26
- GSM9143080 T26_0019 T26
- GSM9143081 T26_0132 T26
- GSM9143082 T26_0196 T26
- GSM9143083 T26_0123 T26
- GSM9143084 T26_0155 T26
- GSM9143085 T26_0190 T26
- GSM9143086 T26_0208 T26
- GSM9143087 T26_0067 T26
- GSM9143088 T26_0174 T26
- GSM9143089 T26_0032 T26
- GSM9143090 T26_0165 T26
+ 253 more — browse all 293 samples with per-sample file links →
- GSE319448 DNA methylation stochasticity is linked to transcriptional variability and identifies convergent epigenetic disruption across genetically-defined subtypes of AML [CellCulture_WGBS] 12 samples shares methylation, identifies, epigenetic
- GSE279619 SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation. 124 samples shares methylation, epigenetic
- GSE275870 Expression profiling of primary and metastatic oral squamous cell carcinoma identifies progression-associated transcriptome changes and therapeutic vulnerabilities 108 samples shares progression, identifies
- GSE281165 TFE3 fusion oncoprotein condensates drive epigenetic reprogramming and cancer progression [CUT&RUN] 43 samples shares progression, epigenetic
- GSE339456 Integrated bulk and spatial transcriptomic analysis identifies progression-associated molecular signatures in biopsy-proven hypertensive nephropathy [RNA-seq] 35 samples shares progression, identifies
- GSE292130 Longitudinal changes in DNA methylation in IDH-mutant glioma fuel disease progression through altered cell state differentiation [scRNA-seq] 31 samples shares methylation, progression
- GSE277273 Multi-omics Sequencing reveals Epigenetic Regulation in Actinic Keratosis and Cutaneous Squamous Cell Carcinoma [850K DNA methylation array] 20 samples shares methylation, epigenetic
- GSE333596 Single-Cell RNA Sequencing Identifies Stem-Like Subpopulations and Their Gene Signature in Lung Adenocarcinoma Progression 12 samples shares progression, identifies
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.