Th17 Cells with Regulatory Phenotype are the Main IL-17F and IL-26 Producers in Palmoplantar Pustulosis
Single-cell RNA-seq · human · 10 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples: 8 distinct titles, 2 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Th17 cells with regulatory phenotype are the main IL-17F and IL-26 producers in palmoplantar pustulosisJCI insight · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304122_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1299251 and SRA study SRP605302. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 10 sample titles: 8 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9144045 6085-AB-2
- GSM9144046 6911-JF-3
- GSM9144047 6929-JF-3
- GSM9144048 6967-JF-5
- GSM9144049 6974-JF-1
- GSM9144050 7027-JF-3
- GSM9144051 7232-JF-1
- GSM9144052 7232-JF-2
- GSM9144053 7351-JF-1
- GSM9144054 7351-JF-2
- GSE299050 Immune Dynamics in Palmoplantar Pustulosis Unveiled by Single-Cell and High-Resolution Spatial Transcriptomics [scRNA-seq] 5 samples shares palmoplantar, pustulosis
- GSE329527 Antigen-restricted Candida albicans Th17 cells link oral-gut immunity and adopt pathogenic features during intestinal inflammation 81 samples shares th17
- GSE313775 Circulating Th1, Th1/17, and Th17 cell bulk RNA sequencing from endometriosis patients and controls 66 samples shares th17
- GSE280021 Dynamics of Th1/Th17 Responses and Antimicrobial Pathways in Leprosy Skin Lesions 45 samples shares th17
- GSE296187 Interleukin-23 promotes a pro-inflammatory Th17 cell state by stabilizing RORγt and suppressing glucocorticoid receptor activity I 28 samples shares th17
- GSE277711 Transcriptional profiling of T cells of healthy individuals after treatment with supernatant of PBMCs of the same individuals treated overnight with sCD14 with isolated T cells cultured in TH17 polarizing condition and T cells treated with GABA overnight 28 samples shares th17
- GSE252771 Persistent dysfunction of Th17 cells in people with HIV on ART and in elite controllers 28 samples shares th17
- GSE282371 Combined Th2 and Th17/22 cytokines models atopic dermatitis pathophysiology in vitro 26 samples shares th17
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.