GEO series
Transcriptomic profiling of irradiated senescent IMR90 cells treated with CDK4/6 or JAK inhibitors
GSE304272
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2025/08/13
GPL34295
Summary
Human fetal lung fibroblasts (IMR90) were induced to undergo senescence via ionizing radiation (IR). Ten days post-IR, RNA was collected from proliferating, senescent+DMSO, senescent+Palbociclib (2 µM), and senescent+Ruxolitinib (2 µM) conditions. Cells were treated on Days 4, 6, 8 and 10 after IR. This dataset examines how CDK4/6 or JAK inhibition affects gene expression in senescent cells.
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Paper (PMID 40766702) ↗
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