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Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis - ON snRNA-seq data

GSE304323 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/06/03 Platform GPL24247
Summary
Triggered by the relevance of Piezo mechanosensitive ion channels in different organs with functions beyond touch and pain sensation, we aimed to investigate Piezo2 in the central nervous system with a focus on the anterior visual system, especially because its role in the CNS lacks understanding. We found a bimodal expression pattern with Piezo1 in progenitors and Piezo2 in mature oligodendrocytes, which was conserved between mice and humans. Using two different OL-specific loss-of-function approaches, we found Piezo2 to be relevant for myelin compactness and white matter integrity in aged mice. Ultrastructural imaging was paired with snRNA-seq analysis and motor function testing that confirmed regulatory roles of Piezo2 in motor function and white matter integrity. We complemented our work with a validation study in human control and multiple sclerosis optic nerve tissue, and found Piezo2 to be downregulated in OLs towards the lesion rim.
Published in
Oligodendrocyte Piezo2 is a regulator of age-dependent myelin integrity and dysregulated in multiple sclerosis
Dyckow-Schubart J, Rabitsch AM, Geywitz C et al. · Communications biology 2026 · PMID 42323468 · doi:10.1038/s42003-026-10530-3
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Also filed as BioProject PRJNA1300375 and SRA study SRP605852. Searching any of these in the dataset finder brings you back here.

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