GEO series
ZIC2 affects oral squamous cell carcinoma stemness by regulating glycerophosphocholine metabolism via LYPLA2
GSE304366
Homo sapiens
Expression profiling by high throughput sequencing
12 samples
2026/04/01
GPL34284
Summary
Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the head and neck. Early-stage OSCC is mainly treated with surgery; for advanced cases, multidisciplinary treatments including surgery combined with adjuvant radiotherapy and chemotherapy are the main approaches. In our previous studies, we found through experiments and bioinformatics analysis that ZIC2 is highly expressed in OSCC and is associated with poor prognosis in patients. Subsequently, we constructed stable knockdown control (sh-NC) and experimental (sh-ZIC2) cell lines of ZIC2 using lentivirus, and conducted high throughput sequencing analysis to detect downstream differentially expressed genes, and performed enrichment analysis on the differentially expressed genes to identify related pathways.
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Paper (PMID 41856987) ↗
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