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Single cell transcriptomic analysis of salivary epithelial cells reveals large-scale dysregulation in bitter taste dysfunction.

GSE304456 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/31 Platform GPL24676
Summary
This study utilized Parse Biosciences's Evercode WT technology to perform scRNA-sequencing of saliva samples from individuals experiencing long COVID associated dysgeusia as well as healthy individuals. The molecular mechanisms behind viral induced dysgeusia are unknown and the salivary epithelium is an easily collected sample that could contain valuable insights into viral mediated dysgeusia. This is the first study to sequence the salivary epithelium and resulted in the identification of large scale dysregulation of epithelial cells in viral induced dysgeusia.
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Direct links to NCBI, no account and no request form: the whole study as GSE304456_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1301335 and SRA study SRP606431. Searching any of these in the dataset finder brings you back here.

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