LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathy
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 6 × hiPSC-CMs, Corrected Isogenic control, vs 6 × hiPSC-CMs, LMNAH222P,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- LMNA p.H222P mutation causes contractile dysfunction via impaired mitochondrial calcium uptake in human cardiac laminopathyCardiovascular research · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304575_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1301814 and SRA study SRP606578. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9153134 hiPSC-CMs, Corrected Isogenic control, rep1 hiPSC-CMs, Corrected Is…
- GSM9153135 hiPSC-CMs, Corrected Isogenic control, rep2 hiPSC-CMs, Corrected Is…
- GSM9153136 hiPSC-CMs, Corrected Isogenic control, rep3 hiPSC-CMs, Corrected Is…
- GSM9153137 hiPSC-CMs, Corrected Isogenic control, rep4 hiPSC-CMs, Corrected Is…
- GSM9153138 hiPSC-CMs, Corrected Isogenic control, rep5 hiPSC-CMs, Corrected Is…
- GSM9153139 hiPSC-CMs, Corrected Isogenic control, rep6 hiPSC-CMs, Corrected Is…
- GSM9153140 hiPSC-CMs, LMNAH222P, rep1 hiPSC-CMs, LMNAH222P,
- GSM9153141 hiPSC-CMs, LMNAH222P, rep2 hiPSC-CMs, LMNAH222P,
- GSM9153142 hiPSC-CMs, LMNAH222P, rep3 hiPSC-CMs, LMNAH222P,
- GSM9153143 hiPSC-CMs, LMNAH222P, rep4 hiPSC-CMs, LMNAH222P,
- GSM9153144 hiPSC-CMs, LMNAH222P, rep5 hiPSC-CMs, LMNAH222P,
- GSM9153145 hiPSC-CMs, LMNAH222P, rep6 hiPSC-CMs, LMNAH222P,
- GSE182219 Impaired vitamin D signaling causes LMNA mutation-related cardiomyopathy 15 samples shares lmna, mutation, impaired
- GSE279133 MYC plus class IIa HDAC inhibiton potentiates mitochondrial dysfunction in non-small cell lung cancer [RNA-seq] 64 samples shares mitochondrial, dysfunction
- GSE278026 Platelets induce endothelial cell mitochondrial dysfunction in myocardial infarction 52 samples shares mitochondrial, dysfunction
- GSE253337 Mitochondrial anomalies in induced pluripotent stem cells from Alzheimer’s disease cases with Presenilin 1 mutation 36 samples shares mitochondrial, mutation
- GSE343456 MCART1 (SLC25A51) deficiency exacerbates mitochondrial dysfunction during MPP+-induced complex I stress 24 samples shares mitochondrial, dysfunction
- GSE307925 Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction 12 samples shares mitochondrial, dysfunction
- GSE338415 Loss of TSPOAP1 exacerbates mitochondrial dysfunction and neuronal apoptosis after intracerebral hemorrhage 10 samples shares mitochondrial, dysfunction
- GSE327103 Glabridin Promotes Melanosome Degradation and Alleviates Melanosome-Induced Mitochondrial Dysfunction in Keratinocytes via Autophagy 9 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.