GEO series
Transcriptomic profiling of meningiomas reveals SMARCB1 mutation-driven immunosuppression via IL-17/CSF1 axis
GSE304666
Homo sapiens
Expression profiling by high throughput sequencing
14 samples
2025/10/30
GPL24676
Summary
Meningiomas with SMARCB1 mutations exhibit distinct immunosuppressive microenvironments. This study performed RNA-seq profiling of 13 human meningioma samples and 1 control sample to identify molecular mechanisms underlying immune evasion. We discovered that SMARCB1 loss upregulates the IL-17/CSF1 axis, leading to increased tumor-associated macrophage infiltration and CD8+ T-cell exhaustion. These findings provide new targets for immunotherapy in refractory meningiomas.
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