PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic Retinopathy [MG_HG]
RNA-seq (gene expression) · human · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 10 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PDZK1 Protects Against RPE Senescence by Targeting the 14-3-3ε-mTOR Axis to Attenuate Early Diabetic RetinopathyAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE304690_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1302330 and SRA study SRP606945. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 10 more — browse all 10 samples with per-sample file links →
- GSE333763 Targeting YAP1 Attenuates Persistent Oxidative Stress-Driven Tubular Cell Senescence 12 samples shares senescence, targeting, attenuate
- GSE316614 Targeting mutation-agnostic disease pathways ameliorates ciliopathy-related mesenchymal drift in RPE 69 samples shares rpe, targeting
- GSE299876 N-acetyl-L-cysteine ethyl ester (NACET) induces the transcription factor NRF2 in the retina and prevents its aging and diabetic retinopathy. [II] 18 samples shares retinopathy, diabetic
- GSE307925 Proliferative diabetic retinopathy subtypes defined by immune defense and endothelial mitochondrial dysfunction 12 samples shares retinopathy, diabetic
- GSE263660 m6A sequencing of vitreous bodies of diabetic retinopathy patients 12 samples shares retinopathy, diabetic
- GSE222337 RNAseq of RPE-hTert cells expressing different levels of predictive reporter construct 50 samples shares rpe
- GSE334036 The Transcriptomic landscape of Kaposi Sarcoma Herpes Virus 43 samples shares rpe
- GSE223513 QuantSeq from Nutlin-3a-treated MCF-7, U2OS, and RPE-1 cells 20 samples shares rpe
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.