Tissue-type plasminogen activator expression is required for proper CNS myelination
RNA-seq (gene expression) · mouse · 15 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 15 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Tissue-type plasminogen activator expression by endothelial cells and oligodendrocytes is required for proper CNS myelinationActa neuropathologica communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE305259_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1304947 and SRA study SRP608424. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 15 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9167451 Spinal cord, P3, replicate 1 Spinal cord, P3,
- GSM9167452 Spinal cord, P3, replicate 2 Spinal cord, P3,
- GSM9167453 Spinal cord, P3, replicate 3 Spinal cord, P3,
- GSM9167454 Spinal cord, P15, replicate 1 Spinal cord, P15,
- GSM9167455 Spinal cord, P15, replicate 2 Spinal cord, P15,
- GSM9167456 Spinal cord, P15, replicate 3 Spinal cord, P15,
- GSM9167457 Spinal cord, P60, replicate 1 Spinal cord, P60,
- GSM9167458 Spinal cord, P60, replicate 2 Spinal cord, P60,
- GSM9167459 Spinal cord, P60, replicate 3 Spinal cord, P60,
- GSM9167460 Spinal cord, P15, CNP WT, replicate 1 Spinal cord, P15, CNP W…
- GSM9167461 Spinal cord, P15, CNP WT, replicate 2 Spinal cord, P15, CNP W…
- GSM9167462 Spinal cord, P15, CNP WT, replicate 3 Spinal cord, P15, CNP W…
- GSM9167463 Spinal cord, P15, CNP KO, replicate 1 Spinal cord, P15, CNP K…
- GSM9167464 Spinal cord, P15, CNP KO, replicate 2 Spinal cord, P15, CNP K…
- GSM9167465 Spinal cord, P15, CNP KO, replicate 3 Spinal cord, P15, CNP K…
- GSE280580 PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination 33 samples shares cns, myelination
- GSE280579 PKC modulator bryostatin-1 therapeutically targets CNS innate immunity to attenuate neuroinflammation and promote remyelination [invitro] 27 samples shares cns, myelination
- GSE263981 Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination [snrna_oligo] 14 samples shares cns, myelination
- GSE263979 Time-resolved function of cell polarity kinases PRKCZ and PRKCI in CNS myelination [bulk_oligo] 11 samples shares cns, myelination
- GSE19403 Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS 12 samples shares cns, myelination
- GSE244474 T cell - DAM feedback loop drives CNS inflammation and neurodegenration in SPG15 at an early age via CCR5-CCL5 interaction [CD3+] 1135 samples shares cns
- GSE269745 Effects of depletion of Irf8 and Mafb on gene expression of adult microglia and CNS border associtated macrophages (CAMs) 44 samples shares cns
- GSE297230 Urokinase plasminogen activator receptor (uPAR) attenuates allergen-induced eosinophil migration and airway hyperresponsiveness through distinct mechanisms [CD45+] 4 samples shares plasminogen, activator
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.