GEO series
The cortical microenvironment drives early immune organization and controls early osteoclastogenesis in bone healing
GSE305266
Mus musculus
Expression profiling by high throughput sequencing
90 samples
2025/12/08
GPL24247
Summary
We employed single-cell RNA sequencing using the 10x Genomics platform to investigate the cellular dynamics and early immune-stromal interactions during fracture healing in young and aged mice. Tissue-resident and infiltrating cell populations were collected from spatially defined bone marrow and cortical compartments from intact femurs as well as day 3 adn day 7 post-osteotomy. In totall, over 178,000 cells were profiled without prior enrichment or cell sorting, capturing the full diversity of immune and stromal cells involved in early bone regeneration. This dataset provides a comprehensive, unbiased atlas of the early fracture healing response and offers novel insights into the spatial regulation of osteoclastogenesis and the alterations with age.
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